Transforming Growth Factor-β in Cancer Therapy, Volume I: by Sonia B. Jakowlew PhD (auth.)

By Sonia B. Jakowlew PhD (auth.)

Transforming development Factor-ß in melanoma remedy, Volumes 1 and a pair of, supply a compendium of findings concerning the function of remodeling development factor-ß (TGF-ß) in melanoma remedy and remedy. the 1st quantity, uncomplicated and medical Biology, is split into 3 elements. half I provides easy ideas of remodeling progress factor-ß signaling in common body structure and melanoma pathobiology. half II investigates reworking progress factor-ß superfamily participants in general and tumor biology. half III information remodeling development factor-ß in irritation and fibrosis.

This volume’s better half, melanoma remedy and treatment, examines reworking development factor-ß in different constructing and complicated cancers and discusses tools of remedy and treatment. jointly, remodeling progress Factor-ß in melanoma treatment, Volumes 1 and a pair of, offer researchers and clinicians with a entire and state of the art reference for the findings concerning the position of remodeling progress factor-ß in biology and melanoma treatment.

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Extra resources for Transforming Growth Factor-β in Cancer Therapy, Volume I: Basic and Clinical Biology

Sample text

Beta-arrestin 2 mediates endocytosis of type III TGF-p receptor and down-regulation of its signaling. Science 2003;301: 1338-1339. 61. Yeo C, Whitman M. Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms. Mol Cell 2001;7 :949-957. 62. Samad TA, Rebbapragada A, Bell E, et al. DRAGON, a bone morphogenetic protein co-receptor. J BioI Chern 2005;280:14122-14129. 63. De Crescenzo G, Hinck CS, Shu Z, et al. Three key residues underlie the differential affinity of the TGFp isoforms for the TGFp type III receptor.

Oh SP, Seki T, Goss KA, et al. Activin receptor-like kinase 1 modulates transforming growth factor~1 signaling in the regulation of angiogenesis. Proc Nat! Acad Sci USA 2000~97:2626-2631. 91. Shi Y, Massague 1. Mechanisms of TGF-~ signaling from cell membrane to the nucleus. Cell 2003~ 113:685-700. 92. Schmierer B, Hill CS. Kinetic analysis of Smad nucleocytoplasmic shuttling reveals a mechanism for transforming growth factor-ji-dependent nuclear accumulation of Smads. Mol Cell Biol 2005~25: 9845-9858.

Chen W, Kirkbride KC, How T, et al. Beta-arrestin 2 mediates endocytosis of type III TGF-p receptor and down-regulation of its signaling. Science 2003;301: 1338-1339. 61. Yeo C, Whitman M. Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms. Mol Cell 2001;7 :949-957. 62. Samad TA, Rebbapragada A, Bell E, et al. DRAGON, a bone morphogenetic protein co-receptor. J BioI Chern 2005;280:14122-14129. 63. De Crescenzo G, Hinck CS, Shu Z, et al. Three key residues underlie the differential affinity of the TGFp isoforms for the TGFp type III receptor.

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