Statistical Design and Analysis in Pharmaceutical Science by Shein-Chung Chow

By Shein-Chung Chow

"Offers a finished, unified presentation of statistical designs and strategies of study for all levels of pharmaceutical development--emphasizing biopharmaceutical functions and demonstrating statistical concepts with real-world examples."

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The randomised Controlled trial 5/18/10 4:01:40 PM Logan et al. (2004) Overall, this is an interesting study that focused on an important issue for public health practice, notably that of improving mobility and quality of life following stroke. The primary outcome demonstrated significant gains of considerable magnitude in the intervention group, compared to the control group, using self-reported measures of mobility. However, the study may have been compromised by including patients of varying ages and post-stroke durations; the study failed to control for additional professional attention; the study was underpowered and the sample size possibly too small to detect statistically significant results on all measures; some principal outcome measures had not been subject to adequate checks for validity, reliability or clinical relevance.

86 (good). We conducted our own investigation of the DKQ and found it difficult to locate details of its psychometric properties (validity and reliability). Chisholm et al. state that they constructed it from previous questionnaires designed originally for use with diabetic adults and included additional items related to younger children’s care. This raises some doubts about its validity and reliability. 117] at [07/18/16]. Copyright © McGraw-Hill Global Education Holdings, LLC. Not to be redistributed or modified in any way without permission.

Report the NNT as 4, which implies that at least 4 people would need to receive the OT intervention in order for one person to benefit in terms of getting out. The closer the value of NNT to 1, the more effective the treatment. Importantly, we should have expected Logan et al. to give a 95% CI for the value for NNT, since NNT is an estimate and not a precise figure. Relative risk versus odds ratio Some researchers prefer to give the odds ratio (OR) instead of the relative risk (see Chapter 16).

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