# Statistical Analysis With Missing Data (Wiley Series in by Roderick J. A. Little

By Roderick J. A. Little

Said specialists at the topic compile assorted resources on equipment for statistical research of knowledge units with lacking values, a pervasive challenge for which regular equipment are of restricted price. mixing thought and alertness, it experiences old ways to the topic, and rigorous but uncomplicated tools for multivariate research with lacking values. is going directly to supply a coherent concept for research of difficulties in accordance with likelihoods derived from statistical versions for the knowledge and the lacking information mechanism. the idea is utilized to a variety of vital missing-data difficulties. huge references, examples, and workouts.

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Additional resources for Statistical Analysis With Missing Data (Wiley Series in Probability and Statistics)

Example text

What Is Computational Proteomics? 3 7 Protein classification, clustering and embedding The goal of protein classification is to organize proteins into functional classes (families). Detecting classes in biological data can help to better understand and characterize the entities in each class and discover global principles that underlie biological systems, similar to the periodic table in chemistry. This is true not only for proteins but for other entities as well, such as interactions or pathways.

Random variables drawn from the distribution P over the alphabet A. In what follows, uppercase letters (Ai ) denote random variables and lowercase letters (ai , ai ∈ A) indicate a specific value of the random variable. Uppercase bold letters denote sequences of random variables, and lowercase bold letters denote sequences of amino acids. For two random sequences A and B, the scores S(A, B) (the global similarity score) and S local (A, B) (the local similarity score) are functions of random variables, and therefore are also random variables.

They are assembled from 20 different amino acids, which have diverse chemical properties. The amino acids form the vocabulary that allows proteins to exhibit a great variety of structures and functions. 4). 4). First T V Codon Table. The 64 possible combinations of nucleotides that make up codons. Note that most amino acids are encoded by more than one codon. Although all coding sequences must start with a start codon, not all proteins start with a methionine because of post transcription and translation modifications of the gene sequence.