Lung cancer therapy annual by Paul A Bunn, Heine H Hansen

By Paul A Bunn, Heine H Hansen

Lung melanoma remedy Annual outlines key elements in early analysis, class and staging, and experiences intensive the present literature, discussing the most recent advancements in therapy and summarizing the latest info within the box of chemotherapy and biologic remedy.

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Skarlos DV, Samantas E, Pectasides D et al, Weekly alternating non-crossresistant chemotherapy for small cell lung cancer with a good prognosis. Am J Clin Oncol 1999;22:87–93. Steward WP, van Pawel J, Gatzemeier U et al, Effects of granulocyte– macrophage colony-stimulating factor and dose intensification of V-ICE chemotherapy in small-cell lung cancer: a prospective randomized study of 300 patients. J Clin Oncol 1998;16:642–60. Thatcher N, Sambrook R, Stephens RJ et al, Dose intensification (DI) with G-CSF improves survival in small cell lung cancer (SCLC): results 69.

Recurrent SCLC In spite of the very high response rate of chemotherapy, with 45–75% CRs reported in limited disease and 20–30% in extensive disease, response durations are usually short, with a median survival of 10–16 months for limited disease and 6–12 months for extensive disease. The 5-year survival rate is 8–10% for all patients with SCLC. Accordingly, most patients relapse and the prognosis for this group of patients is poor. Response is influenced by the time to progression after cessation of first-line therapy.

The treatment-related fatality rate was 8% in the CODE arm versus 1% in the standard arm. As pointed out by Johnson and Carbone,62 this level of fatal toxicity was indeed disturbing, considering that 90% of patients had a performance status of 0 or 1. For that reason, the study was stopped before the intended accrual goal was met. Skarlos et al66 from the Hellenic Cooperative Oncology Group in Greece included a group of SCLC patients with good prognosis, to test whether intensification of weekly chemotherapy with alternated noncross-resistant myelosuppressive agents improved the therapeutic results.

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