Handbook of HER2-Targeted Agents in Breast Cancer by Ricardo H Alvarez, Javier Cortés, Mary Falzon, Michael

By Ricardo H Alvarez, Javier Cortés, Mary Falzon, Michael Gandy, Luca Gianni, Nadia Harbeck, Martine Piccart

This concise guide offers oncologists and different healthcare prone with the most important updates within the box, together with an up-to-date assessment of the present knowing of the biology of the HER2 pathway, an outline of HER2-testing, and evidence-based discussions of obtainable and rising HER2-targeted remedies. a vital scientific textual content for physicians that monitor and deal with sufferers with breast melanoma and require an obtainable, updated survey of the dynamic remedy landscape.

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Extra resources for Handbook of HER2-Targeted Agents in Breast Cancer

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2009;27:6129-6134. 27 Arbeitsgemeinschaft Gynaekologische Onkologie (AGO). Diagnosis and Treatment of Patients with Primary and Metastatic Breast Cancer. AGO Kommission Mamma. 2015. ago-online. de. Accessed November 3, 2015. 28 National Comprehensive Cancer Network (NCCN). Practice Guidelines in Oncology. Breast Cancer. NCCN Website. 2015. org. Accessed November 3, 2015. 29 Tolaney SM, Barry WT, Dang CT, et al. Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer. N Engl J Med.

The first trial aiming at outcome improvement in non-pCR patients, KATHERINE (NCT01772472) has almost finished recruitment. It is run by Roche (Basel, Switzerland) together with the NSABP (National Surgical Adjuvant Breast and Bowel Project) and the GBG (German Breast Group) and randomizes non-pCR patients to T-DM1 (see Chapter 1) versus continuation of trastuzumab for the remainder of the year. Last but not least, given their substantially different pCR rates, endocrine sensitive HER2-positive tumors may need different therapy approaches than hormone-receptor negative HER2-positive tumors [51].

9 Yildiz-Aktas IZ, Dabbs DJ, Bhargava R. The effect of cold ischemic time on the immunohistochemical evaluation of estrogen receptor, progesterone receptor, and HER2 expression in invasive breast carcinoma. Mod Pathol. 2012;25:1098-1105. 10 Farmilo AJ, Stead RH. Fixation and processing. In: Kumar GL, Rudbeck L, eds. Education Guide: Immunohistochemical Staining Methods. 5th edition. Carpinteria, CA: Dako North America; 2009:29-33. 11 Walker RA, Bartlett JMS, Dowsett M, et al. HER2 testing in the UK: further update to recommendations.

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