Genetics of Colorectal Cancer by John D. Potter MD, PhD, David Hunter (auth.), John D. Potter

By John D. Potter MD, PhD, David Hunter (auth.), John D. Potter MD, PhD, Noralane M. Lindor MD (eds.)

The final twenty years have visible a awesome bring up in wisdom of the etiology of colorectal melanoma. a minimum of 3 facets are a lot clearer. First, recognized environmental brokers and behaviors were pointed out that bring up probability (for instance, diets excessive in meat, weight problems, and smoking ) or reduce threat (for instance, diets excessive in plant meals, aspirin, and actual task) of colorectal melanoma. moment, germline mutations in particular genes were pointed out for the key inherited syndromes regarding colorectal melanoma (FAP, Lynch Syndrome, Juvenile Polyposis, MYH-Associated Polyposis, Li-Fraumeni Syndrome) as have versions of genes that adjust the danger linked to the recognized environmental brokers. 3rd, the explicit tissue, mobile, and molecular disturbances that signify the development to assorted subtypes of colorectal melanoma were lately defined. Genetics of Colorectal Cancer presents the main up to date details in each one of those components.

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M. Sato, et al. (1981). ” Cancer Res 41: 1954–7. Newcomb, P. A. and B. E. Storer (1995). ” J Natl Cancer Inst 87: 1067–71. Newcomb, P. , A. C. Bush, et al. (2004). ” Cancer Epidemiol Biomarkers Prev 13(4): 662–6. Newcomb, P. , Y. Zheng, et al. (2007). ” Cancer Res 67(15): 7534–9. , A. Goel, et al. (2005). ” Curr Opin Gastroenterol 21(1): 85–9. , S. Bingham, et al. (2005). ” J Natl Cancer Inst 97(12): 906–16. , A. Chao, et al. (1989). ” Br Med J 299: 1247–50. , D. J. Hunter, et al. (2005). ” JAMA 294(22): 2849–57.

Invasion and metastasis occur rarely. This chapter will summarize the findings from most of the available mouse models of intestinal cancer. M. Perchiniak and J. D. M. Perchiniak and J. Groden be mutated in the majority of sporadic colorectal tumors (Groden et al. 1991; Kinzler et al. 1991). As a result of these initial findings, research has focused on understanding the cellular pathways in which APC participates and how deregulation of these pathways can lead to tumorigenesis. Although APC has many roles in the cell, regulation of the protein β-catenin is the primary function.

P. Weijenberg, et al. (2005). ” Cancer Epidemiol Biomarkers Prev 14(7): 1619–25. Wattenberg, L. W. (1978). ” J Natl Cancer Inst 60(1): 11–8. WCRF Panel (1997). Food, Nutrition and the Prevention of Cancer: A Global Perspective. Washington, DC: American Institute for Cancer Research. Weiss, N. , J. R. Daling, et al. (1981). ” J Natl Cancer Inst 67: 57–60. Whelan, R. , K. D. Horvath, et al. (1999). ” Dis Colon Rectum 42(2): 212–7. , J. S. Shannon, et al. (1997). ” Cancer Epidemiol Biomarkers Prev 6(10): 769–74.

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