ESMO Handbook of Cancer Prevention by Dirk Schrijvers, Hans-Jörg Senn, Håkan Mellstedt, Branko

By Dirk Schrijvers, Hans-Jörg Senn, Håkan Mellstedt, Branko Zakotnik

This guide summarizes the fast-moving global of study into the genetics and prevention of melanoma. a global choice of specialists the following current the issues of so much relevance for oncologists and people concerned professionally with screening and chemotherapy courses.

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Risk or rate difference compares the actual cancer risk or rate among two groups of the population, based on an important characteristic or exposure, by subtracting the risks or rates from one another. Population-attributable risk measures the proportion of cancers that can be attributed to a particular exposure or characteristic. Role of susceptibility and factors influencing individual susceptibility to risks The susceptibility of population subgroups to risk factors is identified and quantitatively assessed, on a statistical basis, by relative risk.

5). Persistent organochlorines Organochlorine compounds include polychlorinated biphenyls (PCBs), pesticides such as DDT, and chlorinated dioxins and furans. These compounds have been of particular interest due to their persistence in the environment and concentration up the food chain, and evidence of their potential endocrinedisrupting properties. Nonetheless, reviews of these compounds have not found persuasive evidence to link them with cancer. Tetrachlorodibenzo-p-dioxin was classified by the IARC as carcinogenic in animal studies and, based on a shared mechanism in cancer development, was also classified as carcinogenic in humans.

Drinking water disinfection by-products Chlorine, the most common water disinfection agent in use worldwide, reacts with organic materials in water to produce a number of by-products, including trihalomethanes (THMs, including chloroform, bromodichloromethane, dibromochloromethane, and bromoform). qxd 12/12/2007 1:51 PM Page 49 The concentration of by-products depends on season, temperature, geographic area, amount of organic matter in the water, and water storage methods. 32) in an analysis that accounted for smoking among subjects; however, the heterogeneity of results across groups suggests that these findings should be interpreted with caution.

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