By John F.R. Robertson, Robert I. Nicholson, Daniel F. Hayes
This article experiences the most recent principles in tumor biology, explains the pharmacologic foundation of the brokers used, and discusses how they're utilized in medical perform. half One provides an summary of the medical value of endocrine remedy, and describes the purposes of the significant sessions of gear, together with antiestrogens, aromatase inhibitors, progestins, and progesterone receptor antagonists. This part additionally discusses ovarian ablation. half bargains with the organic points of endocrine treatments, and relates present knowing of tumor biology and the pharmacologic foundation of hormonal brokers to their scientific functions. one of the subject matters lined are resistance and sensitivity to treatment. half 3 outlines destiny innovations, particularly using mixture endocrine remedy, adjuvant development issue treatment and using anti-invasive brokers. this article is vital for oncologists and pharmacologists alike.
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Additional resources for Endocrine Management of Breast Cancer
However, the small therapeutic gains must be weighed against the additional toxicities associated with chemotherapy27 and individualized decisions regarding risk-to-benefit ratio must be considered. Treatment of metastatic breast cancer While objective response rates for chemotherapy in the treatment of metastatic disease are higher, the duration of response is usually short and treatment is associated with considerable toxicity. Treatment of women with steroid receptor-positive metastatic breast cancer with tamoxifen has lower toxicity and cost.
ER status was available in 1577 (60%). 001). This effect was most pronounced amongst those who were known to be ER-positive. The benefit with goserelin appeared to be somewhat less amongst those who received concurrent adjuvant tamoxifen or adjuvant chemotherapy, but the differences compared with patients who did not receive such concurrent treatments were not statistically significant. 12). Thus, in this study, medical castration with goserelin for 2 years in premenopausal ER-positive patients produced a statistically significant benefit in terms of disease-free survival and a trend toward improvement in overall survival irrespective of concurrent adjuvant tamoxifen or chemotherapy.
Paris: INSERM, 1975: 151–58. Nissen-Meyer R. The role of prophylactic castration in the therapy of human mammary cancer. Eur J Cancer 1967; 3: 395–403. Ludwig Breast Cancer Study Group. Chemotherapy with or without oophorectomy in high risk premenopausal patients with operable breast cancer. J Clin Oncol 1985; 13: 1059–67. Kaufmann M, Jonat W, Blamey R, Schumacher M. The Zebra Study: Zoladex (Goserelin) versus CMF as adjuvant therapy in the management of node positive stage II breast cancer in pre/perimenopausal women aged 50 years or less.