Endocrine Management of Breast Cancer by John F.R. Robertson, Robert I. Nicholson, Daniel F. Hayes

By John F.R. Robertson, Robert I. Nicholson, Daniel F. Hayes

This article experiences the most recent principles in tumor biology, explains the pharmacologic foundation of the brokers used, and discusses how they're utilized in medical perform. half One provides an summary of the medical value of endocrine remedy, and describes the purposes of the significant sessions of gear, together with antiestrogens, aromatase inhibitors, progestins, and progesterone receptor antagonists. This part additionally discusses ovarian ablation. half bargains with the organic points of endocrine treatments, and relates present knowing of tumor biology and the pharmacologic foundation of hormonal brokers to their scientific functions. one of the subject matters lined are resistance and sensitivity to treatment. half 3 outlines destiny innovations, particularly using mixture endocrine remedy, adjuvant development issue treatment and using anti-invasive brokers. this article is vital for oncologists and pharmacologists alike.

Show description

Read or Download Endocrine Management of Breast Cancer PDF

Best cancer books

Johns Hopkins Patients' Guide To Lung Cancer

Johns Hopkins sufferers' advisor to Lung melanoma is a concise, easy-to-follow “how to” consultant that places you at the route to health by means of explaining lung melanoma therapy from begin to end. It publications you thru the overpowering maze of therapy judgements, simplifies the advanced time table that lies forward, and plays the duty of placing jointly your plan of care in layman's phrases.

Anthracycline Antibiotics in Cancer Therapy: Proceedings of the International Symposium on Anthracycline Antibiotics in Cancer Therapy, New York, New York, 16–18 September 1981

F. M. MUGGIA whilst confronted with the inadequacies of present melanoma therapy, we like to examine what the long run may possibly carry. mostly, we take with no consideration the previous, who prefer examine into absolutely new parts. in spite of the fact that, the continual improvement of fertile soil might yield dazzling rewards when you decide to construct at the wisdom of the past--hence, this symposium on anthracycline antibiotics.

Oral Complications of Cancer Chemotherapy

This new paintings on oral issues of melanoma chemotherapy is edited by way of dentists who've made pioneering contributions during this formerly ignored quarter. Their efforts have verified the necessary position of the dentist in oncologic learn and melanoma sufferer administration. The editors have accumulated 9 chapters that might be of curiosity to dentists and dental hygienists, oncology nurses, and all physicians treating melanoma sufferers with chemo­ healing brokers.

Psychological Aspects of Early Breast Cancer

Actual disease can't be successfully taken care of except within the context of the mental components with which it's linked. The physique could have the sickness, however it is the sufferer who's sick. learn psychologists from a couple of diverse backgrounds have, long ago few many years, became more and more to the learn of actual disease, and there's now an in depth literature on preventive behaviors, the function of pressure within the etiology of disorder, the patient's reactions to disease and its remedy, and the physician-patient dating.

Additional resources for Endocrine Management of Breast Cancer

Sample text

However, the small therapeutic gains must be weighed against the additional toxicities associated with chemotherapy27 and individualized decisions regarding risk-to-benefit ratio must be considered. Treatment of metastatic breast cancer While objective response rates for chemotherapy in the treatment of metastatic disease are higher, the duration of response is usually short and treatment is associated with considerable toxicity. Treatment of women with steroid receptor-positive metastatic breast cancer with tamoxifen has lower toxicity and cost.

ER status was available in 1577 (60%). 001). This effect was most pronounced amongst those who were known to be ER-positive. The benefit with goserelin appeared to be somewhat less amongst those who received concurrent adjuvant tamoxifen or adjuvant chemotherapy, but the differences compared with patients who did not receive such concurrent treatments were not statistically significant. 12). Thus, in this study, medical castration with goserelin for 2 years in premenopausal ER-positive patients produced a statistically significant benefit in terms of disease-free survival and a trend toward improvement in overall survival irrespective of concurrent adjuvant tamoxifen or chemotherapy.

Paris: INSERM, 1975: 151–58. Nissen-Meyer R. The role of prophylactic castration in the therapy of human mammary cancer. Eur J Cancer 1967; 3: 395–403. Ludwig Breast Cancer Study Group. Chemotherapy with or without oophorectomy in high risk premenopausal patients with operable breast cancer. J Clin Oncol 1985; 13: 1059–67. Kaufmann M, Jonat W, Blamey R, Schumacher M. The Zebra Study: Zoladex (Goserelin) versus CMF as adjuvant therapy in the management of node positive stage II breast cancer in pre/perimenopausal women aged 50 years or less.

Download PDF sample

Rated 4.35 of 5 – based on 15 votes