DNA Damage and Repair: Volume III: Advances from Phage to by Jac A. Nickoloff, Merl F. Hoekstra

By Jac A. Nickoloff, Merl F. Hoekstra

Jac A. Nickoloff and Merl F. Hoekstra replace and extend their previous acclaimed volumes (Vol. I: DNA fix in Prokaryotes and decrease Eukaryotes and Vol. II: DNA fix in larger Eurkaryotes) with state-of-the-art stories via prime specialists of basic experimental findings approximately DNA fix tactics in melanoma biology. The stories hide quite a lot of themes from viruses and prokaryotes to better eukaryotes, and contain a number of new subject matters, between them the position of recombination in replication of broken DNA, X-ray crystallographic research of DNA fix protein constructions, DNA fix proteins and teleomere functionality, and the jobs of BRCA1 and BRCA2 in DNA fix. Authoritative and updated, DNA harm and service, Vol. III: Advances from Phage to people surveys the speedily relocating study in DNA harm and service, and explains the $64000 useful relationships between varied DNA fix pathways and the connection among DNA fix pathways, melanoma etiology, and melanoma remedies.

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Extra resources for DNA Damage and Repair: Volume III: Advances from Phage to Humans (Contemporary Cancer Research)

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Mutat. Res. 184: 87–98. 15. Chen, D. , and H. Bernstein. 1988. Yeast gene RAD52 can substitute for phage T4 gene 46 and 47 in carrying out recombination and DNA repair. Proc. Natl. Acad. Sci. USA 85: 6821–6825. 16. , and S. Shuman. 1997. Characterization of an ATP-dependent DNA ligase encoded by Haemophilus influenzae. Nucleic Acids Res. 25: 1369–1374. DNA Repair in Bacteriophage 17 17. Colicos, M. , Y. Haj-Ahmad, K. Valerie, E. E. Henderson, and A. J. Rainbow. 1991. Construction of a recombinant adenovirus containing the denV gene from bacteriophage T4 which can partially restore the DNA repair deficiency in xeroderma pigmentosum fibroblasts.

8. Bazemore, L. , M. Takahashi, and C. M. Radding. 1997. Kinetic analysis of pairing and strand exchange catalyzed by RecA. Detection by fluorescence energy transfer. J. Biol. Chem. 272: 14,672–14,682. 9. Blanar, M. , S. J. -E. Armengod, L. W. Ream, and A. J. Clark. 1984.

Binds both ssDNA and ds DNA 3. Promotes renaturation of complementary ssDNA, requires Mg+2, inhibited by 160 mM NaCl – ATP independent. (50) 4. Strand assimilates short oligo and supercoiled DNA, requires Mg+2, ATP independent. (49). 27 F 1. RecF co-precipitates RecO. This is reversed in presence of ATP (27). 2. RecF interacts with RecO even if SSB is present (27) . 1. Binds ssDNA, ATP independent (25, 52). 2. Inhibits RecA joint molecule formation and RecA ATPase activity (52). 3. Binds ATP, dsDNA binding is ATP or ATPγS dependent (53) Binding is stronger for ATPγS than ATP.

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