Current Cancer Research 1986 by Prof. Harald zur Hausen (auth.)

By Prof. Harald zur Hausen (auth.)

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In order to investigate the control of transcription, we introduced the cloned lysozyme gene or lysozyme gene recombinants into oviduct cells and investigated whether the introduced gene is expressed and whether the expression can be influenced by steroids. e. we produced a hybrid gene. Here, we assume that the control regions for steroid-dependent transcription are to be found in the region of the lysozyme gene which we incorporated into the hybrid gene. The objective of these experiments is thus to place the synthesis of the T antigen under hormone control.

47 Significance of Somatic Cell Fusion for the Formation of Metastatic Variants The question as to the significance of somatic cell fusion for the generation of metastatic variants cannot yet be answered at present. It is not known whether such processes also occur in human tumors. Even in animal tumors, the number of investigations is quite insufficient to enable a rough appraisal of how frequently such fusions occur and what percentage of metastatic variants arises from such fusions. However, there are nevertheless some observations on human tumors which are possibly to be seen in a fresh light in view of the new results described.

During or after its synthesis, this RNA is processed; thus, for example, the ends of the molecule are modified, sequences are cut out, and the ends are joined up again; certain proteins are attached and thus form compact RNAprotein complexes. After being locked out through the pores of the nuclear membrane, the messenger RNA molecules attach to ribosomes of the cytoplasm and thus transfer to the cellular apparatus for protein synthesis a copy of the genetic information which directs the synthesis of specific proteins (translation).

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