Cancer in Transplantation: Prevention and Treatment: by Israel Penn (auth.), J. L. Touraine, J. Traeger, H. Bétuel,

By Israel Penn (auth.), J. L. Touraine, J. Traeger, H. Bétuel, J. M. Dubernard, J. P. Revillard, C. Dupuy (eds.)

Malignancies are widespread problems in organ transplantation, regularly because the results of an infection with yes viruses and of long term immunosuppression. The epidemiology confirms that the elevated occurrence issues sure cancers, specially HIV-related dermis cancers and EBV-related lymphoproliferative malignancies.
This ebook covers all at the moment to be had info in this very important subject of the relationships among transplantation and malignancies: preexisting cancers, posttransplant cancers, their etiology and pathophysiology, their prevention and therapy. an important a part of the quantity is dedicated to prophylaxis, early detection and sleek types of remedy in posttransplant lymphomas. As a end of these kind of new facts, the speculation of immunosurveillance merits to be considerably modified.

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Additional info for Cancer in Transplantation: Prevention and Treatment: Proceedings of the 27th Conference on Transplantation and Clinical Immunology, 22–24 May 1995

Sample text

Patients with an acquired cystic kidney disease (ACKD). ACKD is frequently encountered in patients on dialysis (35 to 40%). Its incidence increases with dialysis duration to reach 90% after 10 years. The increased risk of renal tumor makes suitable a careful surveillance including a yearly ultrasound imaging of the kidneys. When should these patients be transplanted? In case of symptomatic tumors, a waiting period of at least 2 years is recommended, although preventing only 61 % of recurrences (Penn 1993).

Patients transplanted from donor with undetected neoplasms Authors Presumed cause of brain death Source of cancer in donor Organ Time mode of transplanted diagnosis (months) Fairman et al. 1980 [13] Male 54 years Traffic accident Melanoma Kidney Kidney Marsh et al. 1987 [14] Female 36 years Choriocarcinoma cerebral haemorrhage (no autopsy) Homburg et al. 1988 [15] Male 43 years Primary brain tumor Baquero et al. 1988 [16] Female 36 years Cerebra hematoma Adenocarcinoma of unknown origin (autopsy) Choriocarcinoma Liver Kidney Kidney Kidney Heart Kidney Liver Kidney Kidney Heart Oesterwitz et al.

It is recommended to have eradicated all lesions before performing the transplantation. Concerning HPV testing with use ofPCR or blotting techniques, its interest in the evaluation of genital HPV infection is poor due to the lack of clinical correlation of these techniques. So they should not be performed routinely. 4. Screening after transplantation Concerning screening for breast, endometrial and ovarian carcinomas, the recommendations are similar to thoses stated for the general population because the incidence of these malignancies remain the same as the one observed in the general population.

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