Cancer in Children: Clinical Management by R. W. Miller (auth.), Paul A. Voûte, Ann Barrett, H. Julian

By R. W. Miller (auth.), Paul A. Voûte, Ann Barrett, H. Julian G. Bloom, Jean Lemerle, Malte K. Neidhardt (eds.)

Cancer in teenagers is the 1st quantity during this new sequence, backed by means of the DICC, at the therapy of melanoma. The editors and authors suppose strongly that extra standardization is required on a global foundation in melanoma remedy. This, after all, is simply attainable if specialists from all international locations sign up for a joint coverage of creating their therapy designs on hand to training oncologists around the globe. present therapy of melanoma will talk about the entire gear and strategies now in use in melanoma treatment. it is going to hide all kinds of melanoma, hence delivering the reader with entire details on melanoma deal with­ ment. the looks of a ebook on paediatric oncology because the first within the sequence is intentional: in fresh a long time there was an incredible development within the remedy of melanoma in childrens, and there's desire for even additional luck during this struggle. we're confident that this ebook and the sequence it really is introducing can help us to make a concerted reaction to the problem of cancer.

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D'Cruz CA, Wimmer RS, Harcke HT, Huff DS, Naiman JL (1983) Veno-occlusive disease of the liver in children following chemotherapy for acute myelocytic leukemia. Cancer 52: 1803-1807 13. Kobrinsky NL, Ramsay NKC, Krivit W (1982) Anthracycline cardiomyopathy. Pediatr Cardiol 3: 265-272 14. Olive D (1981) Complications cardiaques de la chimiotherapie et de la radiotherapie. Arch Fr Pediatr 38: 379-384 15. Muggia FM, Louie AC, Sikic BI (1983) Pulmonary toxicity of antitumor agents. Cancer Treat Rev 10: 221-243 16.

WHO (1977) Handbook for reporting results of cancer treatment. WHO offset publication no 48, Geneva 35 5. Radiation Therapy R. Sandland and A. Barrett The discovery in the late 1890s of the penetrating properties of X-rays and gamma rays produced by naturally occurring radioactive materials led rapidly to their use in the treatment of benign skin conditions and in malignant tumours, with some success. Undesirable effects of these rays, including burns of the skin and epilation, were quickly documented.

Whether those concentrations can also be achieved in the parenchyma of the brain is quite another matter. However, there are now some clinical results in childhood leukaemia showing it is possible to obtain better results with high-dose methotrexate (HDMTX) than with prophylactic brain radiation. Yet another approach has been through attempts to disrupt the blood-brain barrier osmotically, just before administration of methotrexate. Neuwelt et al. [6] reported that in humans a transient, reversible disruption of the blood-brain barrier obtained by intracarotid infusion of mannitol led to increased delivery of MTX to brain tumours and the immediate surrounding brain.

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