Cancer Biology and the Nuclear Envelope: Recent Advances May by Eric C. Schirmer, Jose I. de las Heras

By Eric C. Schirmer, Jose I. de las Heras

This quantity brings jointly many alternative researchers and views overlaying the old and present use of the nuclear envelope in melanoma prognosis and grading, transparent and in all probability proper capabilities of the nuclear envelope in phone cycler law and signaling, chromatin association and gene expression, genome balance, nucleocytoplasmic delivery, mobile mechanical balance and migration, in addition to unforeseen hyperlinks among the nuclear envelope and tumorigenesis.

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Extra resources for Cancer Biology and the Nuclear Envelope: Recent Advances May Elucidate Past Paradoxes

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Ikeguchi M, Oka S, Saito H, Kondo A, Tsujitani S, Maeta M, Kaibara N (1999) Computerized nuclear morphometry: a new morphologic assessment for advanced gastric adenocarcinoma. Ann Surg 229(1):55–61 47. Ladekarl M, Baek-Hansen T, Henrik-Nielsen R, Mouritzen C, Henriques U, Sorensen FB (1995) Objective malignancy grading of squamous cell carcinoma of the lung. Stereologic estimates of mean nuclear size are of prognostic value, independent of clinical stage of disease. Cancer 76(5):797–802 48. Yan J, Zhuo S, Chen G, Wu X, Zhou D, Xie S, Jiang J, Ying M, Jia F, Chen J, Zhou J (2012) Preclinical study of using multiphoton microscopy to diagnose liver cancer and differentiate benign and malignant liver lesions.

Germ-Line Cells and Germ Cell Tumors Since in general the largest differences in lamin expression can be found upon changes in differentiation, one would expect a large number of studies on lamin expression in development of germ-line cells and in developing embryos. Noticeably, The Role of the Nuclear Lamina in Cancer and Apoptosis 31 { { Spermatogenesis Support cells A-type lamins B-type lamins Mouse Human Mouse Human Sertoli cells + + + B1- B2+ Leydig cells + + + B1- B2+ Spermatogonia - - B1+ B2+ B1+ B2+ loss of B2 Primary spermatocytes C2+ - B1+ B1-* B2- C2+ - B1+ B1-* B2- Meiosis I Secondary spermatocytes gain of B3 Meiosis II Spermatids - Spermatozoa - - B1+ B3+ B1-* B2- + Fig.

C. Schirmer morphometry of cytology samples obtained by fine-needle aspiration: preliminary report. Head Neck 35(1):28–34. 22909 Helander K, Hofer PA, Holmberg G (1984) Karyometric investigations on urinary bladder carcinoma, correlated to histopathological grading. Virchows Arch A Pathol Anat Histopathol 403(2):117–125 van Velthoven R, Petein M, Oosterlinck WJ, Zandona C, Zlotta A, Van der Meijden AP, Pasteels JL, Roels H, Schulman C, Kiss R (1995) Image cytometry determination of ploidy level, proliferative activity, and nuclear size in a series of 314 transitional bladder cell carcinomas.

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