By Mahmoud A. Saleh, Jerry N. Blancato, Charles H. Nauman
content material: Biomonitoring for pesticide publicity / C.H. Nauman, John A. Santolucito, and Curtis C. Dary --
Modeling cytochrome P-450 mediated acute nitrile toxicity utilizing theoretical linear solvation strength relationships / George R. Famini, Leland Y. Wilson, and Stephen C. DeVito --
adjustments in biochemical and molecular organic parameters brought on via publicity to dioxin-type chemical substances / Alan Blankenship and Fumio Matsumura --
rules of muscarine receptors as biomarkers of publicity to pesticides / Amira T. Eldefrawi, David A. Jett, and John C. Fernando --
Correlations of molecular connectivity indices with toxicities of natural nitriles / Gordon G. funds --
Computer-aided molecular modeling for improvement of biomarkers for human publicity to insecticides / Mahmoud A. Saleh, Cecil Wallace, Jr., and Jerry N. Blancato --
A biosensor for tracking blood cholinesterases as a biomarker of publicity to organophosphorus anticholinesterase insecticides / Mohyee E. Eldefrawi, Kim R. Rogers, Nabil A. Anis, Roy Thompson, and J.J. Valdes --
Hair as a goal tissue for constructing a organic marker for precursors to 2,5-hexanedione / Deadre J. Johnson, Leon Lack, and Mohamed B. Abou-Donia --
Hemoglobin adducts of insecticides / Frank C. Schnell --
Immunoassay for p-nitrophenol in urine / Kim R. Rogers and J.M. Van Emon --
Isolation of pesticide-binding protein from rat blood / G.L. Larsen, K.L. Davison, J.E. Bakke, and N.M. Bass --
physique burden and nonoccupational publicity review / John A. Santolucito --
continual organophosphorus publicity : biomarkers within the detection of immune disorder and the improvement of lymphomas / David S. Newcombe, Ali M. Saboori, and Ahmed H. Esa --
Validation of a pharmacokinetic version to foretell publicity of floor growth mixer-loader-applicators to chlorophenoxyacetic acid herbicides : comparability to standard techniques / D.G. Baugher --
Dermal absorption and disposition of formulations of malathion in Sprague-Dawley rats and people / Curtis C. Dary, Jerry N. Blancato, Mark Castles, Vijayapal Reddy, Michael Cannon, Mahmoud A. Saleh, and Gordon G. funds --
Physiologically dependent pharmacokinetic types : examples in their use in publicity and hazard evaluation / Jerry N. Blancato and Mahmoud A. Saleh --
Prediction of anticholinesterase job and urinary metabolites of isofenphos : use of a percutaneous physiologically dependent pharmacokinetic-physiologically established pharmacodynamic version / J.B. Knaak, M.A. Al-Bayati, O.G. Raabe, and Jerry N. Blancato --
Analytic answer of a linear physiologically established pharmacokinetic version prototype important in danger evaluation / Robert N. Brown.
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Additional info for Biomarkers of Human Exposure to Pesticides
J. J. Am. Chem. Soc. 1980,102, pp 7196-7206. P. Chem. Phys. Lett. 1984, 111, pp 416420. (63) Korshunov, N. Gig. Primen. Toksikol. Pestits. Klin. Otravlenii 1970,8, pp 398-403. (See Chemical Abstracts # 77(19):122773q). ; ACS Symposium Series; American Chemical Society: Washington, DC, 1993. ch003 Department of Environmental Toxicology and Environmental Health Sciences Center, University of California, Davis, CA 95616-8588 The XB cell hyperkeratinization assay was further developed as an in vitro bioassay tool that can be utilized for estimating 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) equivalents (TEQ) in a complex mixture of halogenated aromatic hydrocarbons.
Epidermal growth factor (EGF) was used at a concentration of 25 ng/mL as a positive control for hyperkeratinization. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1993. ch003 3. BLANKENSHIP & MATSUMURA Exposure to Dioxin-Type Chemicals 45 c ο e X2 < -1000 6 7 Figure 2b. Hyperkeratinization of X B cells in response to ΜΠ Μ TPA and 10" M of two different congeners of tetrachlorobiphenyl (TCB). The absorbance values for TPA are less than zero because the values are relative to a control dish that is in the reference beam.
As for the question of reliability and specificity, we have clearly shown that 2,3,7,8-TCDD produces hyperkeratinization in X B cells in a dosedependent manner with an E D between 1(H° and 10" M, which matches the observations made by Knutson and Poland (19). The high consistency between the results of two independent laboratories further supports the reproducibility of this assay. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1993. ch003 42 BIOMARKERS OF HUMAN EXPOSURE TO PESTICIDES Figure la.