By Sara E. Rosenbaum
Up-to-date with new chapters and subject matters, this ebook presents a entire description of all crucial subject matters in modern pharmacokinetics and pharmacodynamics. It additionally positive factors interactive machine simulations for college kids to scan and detect PK/PD versions in action.
• Presents the necessities of pharmacokinetics and pharmacodynamics in a transparent and revolutionary manner
• Helps scholars larger delight in very important innovations and achieve a better figuring out of the mechanism of motion of substances through reinforcing sensible purposes in either the ebook and the pc modules
• Features interactive desktop simulations, to be had on-line via a significant other site at: http://www.uri.edu/pharmacy/faculty/rosenbaum/basicmodels.html
• Adds new chapters on physiologically dependent pharmacokinetic versions, predicting drug-drug interactions, and pharmacogenetics whereas additionally strengthening unique chapters to higher organize scholars for extra complex applications
• Reviews of the first version: “This is a perfect textbook for these beginning out … and in addition to be used as a reference ebook …." (International Society for the research of Xenobiotics) and “I may suggest Rosenbaum’s publication for pharmacology scholars since it is written from a point of view of drug motion . . . total, this can be a well-written creation to PK/PD …. “ (British Toxicology Society publication)
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Up to date with new chapters and subject matters, this ebook offers a complete description of all crucial themes in modern pharmacokinetics and pharmacodynamics. It additionally positive factors interactive machine simulations for college kids to test and notice PK/PD types in motion. • Presents the necessities of pharmacokinetics and pharmacodynamics in a transparent and revolutionary manner• Helps scholars larger have fun with vital strategies and achieve a better realizing of the mechanism of motion of substances via reinforcing sensible purposes in either the e-book and the pc modules• Features interactive desktop simulations, to be had on-line via a better half site at: http://www.
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Additional resources for Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations
Studies have emphasized the importance of a high log D value. These studies also indicate that mass and polarity are important and suggest that drugs with a molecular mass greater than 500 Da are likely to have poor membrane permeability, particularly if they also possess additional adverse physicochemical characteristics, such as polarity or poor lipophilicity (2). In summary, transcellular permeability is highest for small lipophilic, nonpolar drugs. 4). It is dependent on the size of the junction and on the size of the drug molecule.
Transporters located in the intestinal membrane, the hepatocyte, and the renal tubular membrane influence drug absorption, metabolism, and excretion, respectively, and as a result, the body’s overall exposure to drugs. In other locations, such as the central nervous system, the placenta, and the testis, transporters may have only subtle or negligible influence on the body’s overall exposure to a drug, but by virtue of their control of the access of a small fraction of the dose to these areas are critical in controlling therapeutic and/or toxicological effects.
51 Source: Ref. (1). measuring its distribution between the immiscible phases of n-octanol and water. 4) Because of the very wide range of P values among therapeutic drugs, P values are expressed most conveniently on a log scale. 1 provides the log P values of some therapeutic drugs. Drugs with large positive log P values (felodipine) preferentially partition into the lipid layer. They are lipophilic, would have high permeability across the lipophilic core of the membrane, and would be expected to diffuse easily.