Aseptic Environments and Cancer Treatment by Georges Mathé (auth.), Georges Mathé (eds.)

By Georges Mathé (auth.), Georges Mathé (eds.)

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The ultimate objective is to reduce the risk of infections in patients with AML and thus increase the effectiveness of antitumor therapy. The immediate objective has been attained in that the microorganisms have been markedly reduced as evidenced by quantitative cultures. Studies designed to further improve the antibiotic program and the protective environment are emphasized. Preliminary analysis would indicate that the risk of infection is substantially reduced as evidenced particularly by the proportion of patients who tolerate at least 3 courses of antileukemic chemotherapy.

Pre-cleaning of the rooms has been accomplished with washing and topical antiseptics. Prior to entry, ethylene oxide gas sterilization is practiced. The filtration system thereafter maintains excellent sterility. Air contamination during occupancy by patients not receiving antibiotics is minimal, and approximately 2 log orders lower than the ambient. On most occasions sampled air has been sterile. Since the rooms are highly efficient for preserving a sterile environment, we have set about a randomized study of their efficacy in preventing morbidity and mortality in patients with leukemia.

Cancer Res. 23 (4) Part 2, 271-519 (1963). 6. SKIPPER, H. , SCHABEL, F. , WILCOX, W. : Experimental evaluation of potential anticancer agents. XIII. On the criteria and kinetics associated with "curability" of experimental leukemia. Cancer Chemother. Rep. 35, 1-111 (1964). 7. BODEY, G. : Protected environment for cancer patients. Effects of an oral antibiotic regimen on the microbial flora of patients undergoing chemotherapy. Arch. intern. Med. 122, 23-30 (1968). 8. : A semiquantitative total body skin culture technique for patients in a protected environment.

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