By F. S. Philips (auth.), Franco M. Muggia, Charles W. Young, Stephen K. Carter (eds.)
F. M. MUGGIA whilst confronted with the inadequacies of present melanoma remedy, we wish to examine what the long run may possibly carry. in general, we take without any consideration the previous, who prefer examine into completely new components. besides the fact that, the power improvement of fertile soil might yield awesome rewards in case you decide to construct at the wisdom of the past--hence, this symposium on anthracycline antibiotics. even if the anthracycline antibiotics symbolize a lot of the current and way forward for melanoma therapy, their genuine use c stretches again slightly twenty years to the pioneering efforts of Aurelio Di Marco, who characterised the antitumor homes of daunomycin and adriamycin. * The scientific software of those compounds heralded a decade of pleasure between oncologists facing pediatric tumors, breast melanoma, leukemias, and lymphomas, and opened new wish for sufferers bothered with sar comas and numerous different tumors that have been deemed - sistant to chemotherapy. those successes have been tempered with the conclusion that the antitumor influence of anthracyclines should be accomplished every now and then basically on the very excessive expense of risking cardiac decompensation and, nearly consistently, with the prevalence of alopecia and different acute toxicities. This list of prior achievements and difficulties has slowly given strategy to a gift more and more illuminated by means of our skill to switch the distressing toxicities of those brokers. distinctive scientific reports supplemented by means of creative laboratory versions have progressively elucidated mechanisms and chance components im plicated within the cardiomyopathy.
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F. M. MUGGIA while confronted with the inadequacies of present melanoma remedy, we wish to examine what the longer term might carry. ordinarily, we take without any consideration the prior, who prefer examine into completely new parts. in spite of the fact that, the continual improvement of fertile soil may perhaps yield astonishing rewards if you happen to decide to construct at the wisdom of the past--hence, this symposium on anthracycline antibiotics.
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Extra info for Anthracycline Antibiotics in Cancer Therapy: Proceedings of the International Symposium on Anthracycline Antibiotics in Cancer Therapy, New York, New York, 16–18 September 1981
Eur. J. Clin. Bioi. , ~, 572. 20. Meriwether WD, Bachur NR. 1972. , 32, 1137. 21. Noel G, Trouet A, Zenebergh A, Tulkens P. 1975. Adriamycin Review. European Press Medikon, Ghent, Belgium, 99. 22. Giuliani F, Casazza AM, Di Marco A, Savi G. 1981. Cancer Treat. , ~, 267. 23. Arcamone F, Penco S, Vigevani A, Redaelli S, Franchi G, Di Marco A, Casazza AM, Dasdia T, Formelli F, Necco A, Soranzo C. 1975. J Med. , ~, 703. 24. Casazza AM, Di Marco A, Bertazzoli C, Formelli F, Giuliani F, Pratesi G. 1978.
As regards antitumor activity, the general approach to these studies was to set up experimental models which could allow the identification of new anthracycline analogs having in respect to the parent compounds, either greater antitumor activity against tumors already sensitive to anthracyclines, or activity against tumors with natural or acquired resistance. I will here describe the antitumor effectiveness against experimental tumors of some anthracycline analogs which have been selected because of outstanding antitumor properties or because of a higher therapeutic index in respect to DX.
Cancer Chemother. Japan Sci. Soc. Press, Tokyo and University Park Press, Baltimore, 297. 31. Formelli F, Casazza AM. 1981. 12th Int. , Florence, July 19-24, 1981, Abstracts, 114. 32. Broggini M, Colombo T, Martini A, Donelli MG. 1980. Cancer Treat. , 64, 897. 33. Casazza AM, Di Marco A, Bonadonna G, Bonfante V, Bertazzoli C, Bellini 0, Pratesi G, Sala L, Ballerini L. 1980. Anthracyclines: current status and new developments. New York, Academic Press, 403. 34. Villani F, Favalli L, Piccinini F.