Advances in Twin and Sib-pair Analysis by Tim D. Spector, Harold Snieder, Alex J. MacGregor

By Tim D. Spector, Harold Snieder, Alex J. MacGregor

Dual and relations facts have ordinarily been used to quantify the genetic and environmental contribution to affliction. throughout the software of latest analytical techniques, those designs may also supply robust types during which the quest for particular genes underlying non-Mendelian ailments might be optimised. This publication discusses the state of the art in dual and sib-pairs research of complicated ailments either from the viewpoint of epidemiology (study layout, topic choice, sampling thoughts) and biostatistics (path research, survival research, linkage research, organization studies). Novel methods are mentioned within which twins and sib-pairs can be utilized to satisfy the problem of selecting the site and serve as of genes underlying advanced qualities. This ebook will entice quite a lot of biomedical scientists attracted to the genetic foundation of affliction, epidemiologists, molecular biologists, human geneticists and scholars.

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The transmission disequilibrium test and the extension of variance components analysis to incorporate data from Quantitative Trait Loci (QTLs) are reviewed. Other subjects have also been interjected. These include an appraisal of the contribution of data from developing countries to twin and sib-pair studies and an assessment of the impact of phamacognetics on medicine and therapeutics. Page xiv In the editorial process, we have unashamedly used our own understanding (and lack of it) as our guide.

J. MacG JULY 1999 Page xv Acknowledgments We would like to thank all the people that made the first workshop possible including Pat Harris, Carol Roach and William Carter. We are also grateful to our main meeting sponsors, Gemini Research Ltd of Cambridge, UK, with additional thanks to SKB and Zeneca PLC for their support. S. S. J. MacG JULY 1999 Page 1 1 The History of Twin and Sibling-Pair Studies Tim D. Spector Page 2 ABSTRACT This chapter briefly discusses the origins of the classical twin study and what is today known as the sib pair method.

Measurement of twins. Archives of Philosophy, Psychology and Scientific Methods, 1905; 1: September. 6 Fisher RA. The genesis of twins. Genetics 1919;4: 489-499 7 Weismann A. The evolutionary theory 1904;2: 44-45 (quoted by Merriman) 8 Danforth CH. Is twinning hereditary? Journal of Heredity 1916;7: 195 9 Newman HH. The biology of twins. University of Chicago Press 1917, pp 1-185 10 Davenport CB et al. Twins. Journal of Heredity. 1919: december (quoted by Merriman) 11 Sharp. Introduction to Cytology, 1921: p357 (quoted by Merriman) 12 Merriman C.

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