Advances in Cancer Research, Volume 106 by George F. Vande Woude

By George F. Vande Woude

Advances in melanoma examine presents necessary details at the interesting and fast-moving box of melanoma study. the following, once more, striking and unique studies are awarded on a number of subject matters, together with liposome-based chemotherapy and immunotherapy, human polyomaviruses, the position of micro RNAs in CLL, and melanoma and ldl cholesterol.

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Mackay, I. , Lambert, S. , Brennan, D. , Storch, G. , Sloots, T. , and Wang, D. (2007). Identification of a novel polyomavirus from patients with acute respiratory tract infections. PLoS Pathog. 3, e64. Gayther, S. , Batley, S. , Chin, S. , Sowter, H. , Delhanty, J. , Ponder, B. , et al. (2000). Mutations truncating the EP300 acetylase in human cancers. Nat. Genet. 24, 300–303. , DeCaprio, J. , and Roberts, T. M. (2000). pRB-dependent, J domainindependent function of simian virus 40 large T antigen in override of p53 growth suppression.

Although as many as 110 cellular proteins have been reported to bind pRB (Morris and Dyson, 2001), the E2F family of transcription factors appears to be the most important target in tumor suppression and cell cycle control. E2F members normally heterodimerize with members of the DP family to facilitate DNA binding. pRB effects transcriptional repression in large part by recruiting chromatin remodeling factors. These include histone deacetylases, hBRM, BRG1, and SUV39H1. The binding sites for LxCxE-containing proteins and E2F are distinct, although they both map within the pRB pocket domain.

J. (2002). Regions and activities of simian virus 40 T antigen that cooperate with an activated ras oncogene in transforming primary rat embryo fibroblasts. J. Virol. 76, 3145–3157. Becker, J. , and Schrama, D. (2009). MC polyomavirus is frequently present in Merkel cell carcinoma of European patients. J. Invest. Dermatol. 129, 248–250. , Klapper, P. , Vallely, P. , Cleator, G. , and Khoo, S. H. (2004). Detection of BK virus and JC virus DNA in urine samples from immunocompromised (HIV-infected) and immunocompetent (HIV-non-infected) patients using polymerase chain reaction and microplate hybridisation.

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